LymphedemaV1, Main, Exploration, bibRecord, 000A42

The Lymphatic System: Integral Roles in Immunity

Identifieur interne : 000A42 ( Main/Exploration ); précédent : 000A41; suivant : 000A43

The Lymphatic System: Integral Roles in Immunity

Auteurs : Gwendalyn J. Randolph [États-Unis] ; Stoyan Ivanov [États-Unis] ; Bernd H. Zinselmeyer [États-Unis] ; Joshua P. Scallan [États-Unis]

Source :

Annual review of immunology [ 0732-0582 ] ; 2016.

RBID : PMC:5551392

Abstract

The lymphatic vasculature is not considered a formal part of the immune system, but it is critical to immunity. One of its major roles is in the coordination of the trafficking of antigen and immune cells. However, other roles in immunity are emerging. Lymphatic endothelial cells, for example, directly present antigen or express factors that greatly influence the local environment. We cover these topics herein and discuss how other properties of the lymphatic vasculature, such as mechanisms of lymphatic contraction (which immunologists traditionally do not take into account), are nonetheless integral in the immune system. Much is yet unknown, and this nascent subject is ripe for exploration. We argue that to consider the impact of lymphatic biology in any given immunological interaction is a key step toward integrating immunology with organ physiology and ultimately many complex pathologies.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551392

DOI: 10.1146/annurev-immunol-041015-055354
PubMed: 27860528
PubMed Central: 5551392

Affiliations:

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The Lymphatic System: Integral Roles in Immunity

The Lymphatic System: Integral Roles in Immunity

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